For some people, everyday cues keep pulling the brain toward the same bad decisions.
Society for Neuroscience

However, this system does not work the same way for
everyone. For people with compulsive disorders, addictions, or anxiety, these
learned associations can become overly powerful. Instead of serving as helpful
guides, cues may start to dominate decision making. Individuals may feel pulled
toward certain sights or sounds or strongly driven to avoid them, even when
doing so leads to poor outcomes.
Studying Biased Decision Making
To better understand how this happens, Giuseppe di
Pellegrino of the University of Bologna led a study focused on how people learn
from cues and how this learning can sometimes go wrong. The research examined
maladaptive decision making, which refers to choices that continue to cause
harm or disadvantage despite repeated negative consequences.
As described in their JNeurosci paper, the
researchers found that people differ widely in how much they rely on
environmental cues when making decisions. Some individuals depend heavily on
surrounding visuals and sounds to guide their choices, while others rely on
them far less.
Why Some People Struggle to Adapt
The study also revealed an important problem for those who
are highly cue driven. When familiar cues start to signal riskier or less
favorable outcomes, these individuals often struggle to adjust. They may have
difficulty updating their beliefs about what those cues mean and unlearning old
associations that no longer apply. In practical terms, this means the brain
keeps responding as if nothing has changed, even when the situation clearly
has.
As a result, disadvantageous decision making can persist
over time. Instead of adapting to new information, people may repeat the same
risky or harmful choices again and again.
Implications for Addiction and Anxiety
According to the researchers, these findings suggest that
some people have stronger cue sensitivity than others, combined with a reduced
ability to revise what they have learned about those cues. This combination may
help explain why certain decision patterns are so hard to break.
The research team plans to continue studying associative
learning in patient populations. Their goal is to better understand whether the
harmful decision patterns -- which characterize addictions, compulsive
disorders, and anxiety -- are more likely to occur in people who are especially
sensitive to the sights and sounds that influence their choices.
Journal Reference:
- Luigi
A.E. Degni, Lorenzo Mattioni, Claudio Danti, Valentina Bernardi, Gianluca
Finotti, Marco Badioli, Francesca Starita, Alireza Soltani, Giuseppe di
Pellegrino, Sara Garofalo. Reduced Pavlovian value updating alters
decision-making in sign-trackers. The Journal of Neuroscience,
2025; e1465252025 DOI: 10.1523/JNEUROSCI.1465-25.2025