Flu shots prevent 80% of death in kids
During eight respiratory illness seasons, estimated influenza vaccine effectiveness (VE) against death in US children was 80% overall, 77% in those who had underlying medical conditions, and 87% among those without such conditions, Centers for Disease Control and Prevention (CDC) researchers report today in Pediatrics.
The team used data from the US Influenza Associated
Pediatric Mortality Surveillance System and survey data to estimate VE against
death and assess vaccination status in children aged 6 months to 17 years who
died of their infections from August 2016 through July 2025. The study excluded
the 2020-21 flu season.
“Seasonal influenza vaccination has been shown to reduce the
risk of influenza and severe complications among children aged 6 months
and older,” the study authors noted. “Since 2010, reported numbers of
influenza-associated pediatric deaths among children younger than 18 years
have ranged from 37 during the 2011 to 2012 season to 289 during the 2024 to
2025 season.”
Over half of flu deaths were in otherwise healthy
children
In total, 1,234 children aged 6 months to 17 years died
of flu. Overall, 48% of pediatric deaths occurred in children with one or more
underlying medical conditions and 52% in those without such conditions.
Of deaths in children with at least one high-risk condition, the greatest proportion of flu vaccination was in those with non-asthma lung disorders (35%), followed by immune-weakening conditions (33%) and genetic and mitochondrial disorders (29%) and was lowest among those with obesity (18%), diabetes (11%), and hemoglobinopathies such as sickle cell disease (8%).
Among 1,086 deaths with flu vaccination data, only 23% of
530 children with chronic conditions and 13% of 556 children without these
conditions were fully vaccinated against flu. By season, the proportion of flu
deaths in children vaccinated in the current year ranged from 26% in 2018-19 to
9% in 2024-25.


























